Elastography
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Optical coherence elastography (OCE) is a promising technique for high-resolution strain imaging in ocular tissues. It combines standard structural imaging with an external deformation stimulus to retrieve material properties of e.g. the cornea. We track changes in magnitude and phase of the backscattered light signal, and subsequently convert them into displacement and strain maps.
The following images show the morphological (standard) image, the phase difference map and the strain image:
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Recent Congress Contributions
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Kling, S. (2019). High-resolution corneal strain maps after patterned corneal cross-linking (CXL), CXL Experts' meeting, Zurich (Switzerland)
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Kling, S., & Khodadadi, H. (2019). Optical coherence elastography based corneal strain mapping during low-amplitude intraocular pressure modulation, ARVO Annual Meeting, Vancouver (Canada)
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Kling, S., & Khodadadi, H. (2019). Corneal Strain after UV-Riboflavin Cross-Linking Measured by Optical Coherence Elastography, Imaging the Eye Conference, Vancouver (Canada)
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Kling, S. (2019). High-resolution corneal strain maps after patterned corneal cross-linking (CXL), CXL expert's meeting, Zurich (Switzerland)
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Further Publications
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Kling, S., Khodadadi, H., & Goksel, O. (2019). Optical coherence elastography based corneal strain imaging during low-amplitude intraocular pressure modulation. Frontiers in Bioengineering and Biotechnology.
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Kling, S. (2020). Optical coherence elastography by ambient pressure modulation for high-resolution strain mapping applied to patterned cross-linking. Journal of the Royal Society Interface, 17(162), 20190786.
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Kling, S., & Hafezi, F. (2017). Corneal biomechanics – a review. Ophthalmic and Physiological Optics, 37(3), 240-252.
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Akca, B. I., Chang, E. W., Kling, S., Ramier, A., Scarcelli, G., Marcos, S., & Yun, S. H. (2015). Observation of sound-induced corneal vibrational modes by optical coherence tomography. Biomedical optics express, 6(9), 3313-3319.
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Kling, S. , Akca, I. B., Chang, E. W., Scarcelli, G., Bekesi, N., Yun, S. H., & Marcos, S. (2014). Numerical model of optical coherence tomographic vibrography imaging to estimate corneal biomechanical properties. Journal of The Royal Society Interface, 11(101), 20140920.
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Scarcelli, G., Kling, S., Quijano, E., Pineda, R., Marcos, S., & Yun, S. H. (2013). Brillouin microscopy of collagen crosslinking: noncontact depth-dependent analysis of corneal elastic modulus. Investigative ophthalmology & visual science, 54(2), 1418-1425.
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