Normothermic Liver Perfusion
Long-term normothermic liver perfusion of discarded human organs provides unique research opportunities to study the liver as an isolated system, outside of the human body. This can be leveraged to improve long-term preservation approaches and develop novel treatments that can be applied ex-vivo.
Selected Publications
Ding et al. Glucose controls lipolysis through Golgi PtdIns4P-mediated regulation of ATGL. Nature Cell Biology (2024)Eshmuminov et al. An integrated perfusion machine preserves injured human livers for 1 week. Nature Biotechnology (2020)
Clavien et al. Transplantation of a human liver following 3 days of ex situ normothermic preservation. Nature Biotechnology (2022)
Schuler et al. Observations and findings during the development of a subnormothermic/normothermic long-term ex vivo liver perfusion machine. Artificial Organs (2023)
