Normothermic Liver Perfusion

Long-term normothermic liver perfusion of discarded human organs provides unique research opportunities to study the liver as an isolated system, outside of the human body. This can be leveraged to improve long-term preservation approaches and develop novel treatments that can be applied ex-vivo.

Selected Publications

Eshmuminov et al. An integrated perfusion machine preserves injured human livers for 1 week. Nature Biotechnology (2020)

Clavien et al. Transplantation of a human liver following 3 days of ex situ normothermic preservation. Nature Biotechnology (2022)

Schuler et al. Observations and findings during the development of a subnormothermic/normothermic long-term ex vivo liver perfusion machine. Artificial Organs (2023)